Endocrine Abstracts

Introduction: Although the cause and effect relationship between the hypophyseal deficiency and osteoporosis is known well, the number of studies concerning bone mineral density (BMD) in patients with Sheehan’s syndrome (SS) are scarce. We aimed to investigate the relationship between BMD and deficient hormones in patients with newly-diagnosed Sheehan’s syndrome.Material and methods: Thirty-four patients with SS and age-gender-weight matched 22...

We report a case of 28-year-old girl with panhypopituitarism and ectopic neurohypophysitis due to absent pituitary stalk. She was admitted to endocrinology policlinic with short stature, growth retardation and primary amenorrhea. Basal hormones indicated tahat she has secondary hypothyroidism, adrenal insufficiency, hypogonadism and GH insufficiency. Peak cortisol response to the short ACTH test was normal but inadequate to insulin tolerance test. The other dynamic pituitary f...

Introduction: Silent corticotroph adenomas (SCAs) are uncommon pituitary tumors, immunoreactive for ACTH, but without clinical evidence of hypercortisolism and present with local mass effects and some endocrine dysfunction. Case 43 years old male patient was diagnosed with pituitary tumor which was 5×3 cm in size. In history, 6 months ago he applied to another hospital with syncope and operated transsphenoidally. But these datas are unreachable. He had been suffering from...

Introduction: Wegener granulomatosis is a necrotizing granulomatous small-vessel vasculitis. It typically affects the upper respiratory tract, lungs, and kidneys but can involve virtually any organ including the pituitary. Pituitary involvement in wegener granumatosis is rare.Case: A 50-year-old woman was admitted to the hospital with severe dyspne for 2 years and stridor for a month. During her hospitalization, her sodium level was noted to be persisten...

Introduction: The beneficial effects of vitamin D against gastrointestinal polyps and cancer in the gastrointestinal system as a whole remain unknown and relevance in repeat populations remain contraversial. Also in most studies the role of accompanying hypocalcemia itself is often neglected. For this reason we included only patients with low vitamin D levels and investigated the presence of gastric and colonic polyps.Methods/design: Between March 2011 a...

Lymphocytic hypophysitis (LH), an uncommon pituitary disorder that is considered an autoimmune disease. The disease shows a striking female predilection of ~9:1 and commonly affects young women during late pregnancy or in the postpartum period. Less frequently, it has also been observed in men and postmenaposal woman. Partial or total hypopituitarism can be in LH. In the early stage, the pituitary gland is enlarged like a pituitary tumor, from which it cannot be distinguished ...

Patients with inappropriate TSH syndrome have elevated serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations and normal or slightly elevated serum thyroid stimulating hormone (TSH) level. Inappropriate TSH syndrome include generalized resistance to thyroid hormone (GRTH), pituitary resistance of thyroid hormone (PRTH) and TSHoma.We report here three cases that the first patient has GRTH, the second has TSHoma and third patient has PRT...

Impaired glucose tolerance (IGT) and metabolic syndrome (MS) is considered as the pre-diabetic stages. Recently, it has been suggested that inflammation is associated with the components of MS and it may also have a role in the development of type 2 Diabetes Mellitus (DM). The aim of this study was to investigate the effects of inflammation in the pathogenesis of DM.The study groups consisted of 51 patients with type 2 DM, 28 patients with MS, and 26 pat...

The patient who was operated because of pituitary macroadenoma causing acromegaly disease had insufficient suppression respond of growth hormone to postoperative oral glucose tolerance test (OGTT). OCT LAR treatment had been started. On the 15.month of the therapy, the patient presented with failure of menstruation since four months, so pregnancy test was performed and pregnancy was diagnosed. The patient had used OCT LAR during the period without knowing that she was pregnant...

Cortex protecting surgery for bilateral pheochromocytoma protects the patient from adrenal insufficiency. Risk of relapse is low. 35 years old woman had paroxysmal seizures and hypertension crises for the last year which became more frequent in the last 10 days. She had thyroidectomy and under the use of levothyroxine the patient. Because of a nodule on ultrasonography and paternal history of MEN 2A which led to a check of calcitonin level that resulted 8 times higher than the...